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. 2009 Nov 15;20(22):4686–4695. doi: 10.1091/mbc.E08-11-1123

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© 2009 by The American Society for Cell Biology

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Figure 7. — Effects of expressing Hec1-binding deficient Hice1 mutant on spindle morphology. Cells were infected with retrovirus expressing Hice1-siRNA-resistant Hice1-FL-GFP, Hice1ΔCoil1-GFP. (A) In mitotic cells, Hice1-FL-GFP and Hice1ΔCoil1-GFP colocalize with the spindle maker β-tubulin as revealed by coimmunostaining. (B) The Hice1-FL-GFP or Hice1ΔCoil1-GFP cells were transfected with Hice1 siRNA for 2 d to deplete endogenous Hice1. Images showed the spindle configurations as revealed by costaining with γ-tubulin. (C) Bar graph was used to show the occurrence of spindles with multiple poles in each group. Bars (B and C), 10 μm.