Table 1.
Baseline clinical and biochemical characteristics between aspirin users and non-users in the complete cohort (n = 6,454)
|
Overall (n = 6,454) |
Aspirin users (n = 1,619) |
Non-aspirin users (n = 4,835) |
p-value‡ | |
| Age, years | 58.0 ± 12.8 | 65.7 ± 10.2 | 55.4 ± 12.6 | < 0.001 |
| Male, n (%) | 2,928 (45.4) | 819 (50.6) | 2,109 (43.6) | < 0.001 |
| Duration of diabetes, years | 8.1 ± 6.9 | 11.4 ± 7.5 | 7.0 ± 6.3 | < 0.001 |
| Smoking (current), n (%) | 1,033 (16.1) | 253 (15.7) | 780 (16.2) | < 0.001 |
| Alcohol (current), n (%) | 517 (8.1) | 100 (6.2) | 417 (8.7) | < 0.001 |
| Systolic blood pressure, mmHg | 136.2 ± 20.3 | 142.6 ± 21.7 | 134.1 ± 19.4 | < 0.001 |
| Diastolic blood pressure, mmHg | 75.1 ± 10.6 | 75.1 ± 11.2 | 75.1 ± 10.3 | 0.848 |
| Body weight, kg | 63.4 ± 12.3 | 63.3 ± 11.8 | 63.5 ± 12.5 | 0.583 |
| Body mass index, kg/m2 | 25.2 ± 3.9 | 25.3 ± 3.7 | 25.2 ± 4.0 | 0.135 |
| Waist circumference (cm): Males | 88.7 ± 9.6 | 90.1 ± 8.7 | 88.4 ± 9.8 | < 0.001 |
| Females | 83.8 ± 10.0 | 85.5 ± 9.9 | 83.6 ± 9.9 | < 0.001 |
| Glycosylated haemoglobin, % | 7.59 ± 1.69 | 7.72 ± 1.68 | 7.57 ± 1.69 | < 0.001 |
| Fasting plasma glucose, mmol/L | 8.59 ± 3.10 | 8.57 ± 3.18 | 8.59 ± 3.09 | 0.046 |
| Total cholesterol, mmol/L | 5.21 ± 1.05 | 5.09 ± 1.06 | 5.23 ± 1.05 | 0.167 |
| LDL cholesterol, mmol/L | 3.19 ± 0.95 | 3.06 ± 0.97 | 3.21 ± 0.94 | 0.286 |
| HDL cholesterol, mmol/L | 1.30 ± 0.38 | 1.26 ± 0.33 | 1.31 ± 0.39 | < 0.001 |
| Serum triglycerides, mmol/L † | 1.45 (1.43, 1.47) | 1.58 (1.53, 1.64) | 1.43 (1.41, 1.45) | < 0.001 |
| Serum creatinine, μmol/L † | 83.2 (82.4, 83.9) | 97.1 (95.0, 99.2) | 79.1 (78.3, 79.8) | < 0.001 |
| Estimated GFR# | 74.6 (73.8, 75.3) | 58.6 (56.8, 60.5) | 77.6 (76.8, 78.5) | < 0.001 |
| Spot urine ACR, mg/mmol † | 3.7 (3.6, 3.9) | 8.3 (7.4, 9.2) | 2.9 (2.7, 3.0) | < 0.001 |
| Blood haemoglobin, g/dL | 13.7 ± 1.6 | 13.4 ± 1.7 | 13.8 ± 1.6 | < 0.001 |
| Peripheral vascular disease, n (%) | 400 (6.2) | 223 (13.8) | 177 (3.7) | < 0.001 |
| Lower extremity amputation, n (%) | 26 (0.4) | 13 (0.8) | 13 (0.3) | 0.003 |
| Ischaemic heart disease, n (%) | 281 (4.4) | 240 (14.8) | 41 (0.8) | < 0.001 |
| Myocardial infarction, n (%) | 67 (1) | 65 (4) | 2 (0) | < 0.001 |
| Coronary revascularisation, n (%) | 77 (1.2) | 75 (4.6) | 2 (0) | < 0.001 |
| Congestive heart failure, n (%) | 119 (1.8) | 85 (5.3) | 34 (0.7) | < 0.001 |
| Stroke, n (%) | 256 (4) | 221 (13.7) | 35 (0.7) | < 0.001 |
| Atrial fibrillation, n (%) | 70 (1.1) | 35 (2.2) | 35 (0.7) | < 0.001 |
Mean ± SD or number of patients (%) or † geometric mean (95% confidence interval).
‡ By Chi-square test for categorical variables and t-test for continuous variables
#Based on the abbreviated MDRD (Modification of Diet in Renal Disease) equation for Chinese (ref. 42)
LDL and HDL = low- and high-density lipoprotein, ACR = albumin-to-creatinine ratio, GFR = glomerular filtration rate.