Table 1.
Characteristics of 394 prostate cancer cases by biochemical recurrence (BCR) status following prostatectomy surgery
| Characteristic | BCR (n = 76) | No BCR (n = 318) | p-valuea |
|---|---|---|---|
| Age (mean ± SE) | 60.8 ± 6.0 | 61.0 ± 6.8 | 0.73 |
| African-Americans (%) | 30 (39.5%) | 138 (43.4%) | 0.53 |
| Average time of follow-up/observation (months)b | 66.9 ± 24.7 | 61.0 ± 22.7 | 0.09 |
| PSA at diagnosis (ng/ml) | 10.6 ± 9.6 | 6.0 ± 4.3 | <0.001 |
| High tumor gradec | 35 (46.1%) | 77 (24.2%) | <0.001 |
| Advanced tumor staged | 30 (39.7%) | 43 (13.5%) | <0.001 |
| Cigarette smoking status | |||
| Never | 23 (33.3%) | 119 (38.1%) | 0.42 |
| Former | 46 (60.5%) | 156 (51.7%) | |
| Current | 7 (9.2%) | 33 (10.3%) | |
| GSTM1 null | 32 (42.1%) | 123 (38.7%) | 0.58 |
| GSTT1 null | 15 (19.7%) | 67 (21.1%) | 0.80 |
| GSTP1 Ile105Val | |||
| Ile/Ile | 26 (34.2%) | 117 (36.8%) | 0.22 |
| Ile/Val | 34 (44.7%) | 159 (50.0%) | |
| Val/Val | 16 (21.1%) | 42 (13.2%) | |
| Total number of high risk genotypes (combined)e | |||
| 0 | 11 (14.5%) | 53 (16.7%) | 0.96 |
| 1 | 36 (47.4%) | 149 (46.9%) | |
| 2 | 26 (32.4%) | 106 (33.3%) | |
| 3 | 3 (4.0%) | 10 (3.1%) | |
a p-value from t-test or χ2 test, as applicable
bTime from study entry to date of last PSA test for the entire cohort
cHigh-grade defined as a total Gleason score of eight or higher or a primary Gleason score of four or higher
dAdvanced tumor stage defined as Stage 3a or higher
eNumber of GSTM1 null, GSTT1 null and GSTP1 105Val alleles