Table 3.
Risk of prostate cancer BCR after prostatectomy associated with GST polymorphisms by race and tumor grade
| Genotype | Total sample | Caucasians | African-Americans | |||
|---|---|---|---|---|---|---|
| Low grade | High grade | Low grade | High grade | Low grade | High grade | |
| GSTM1 |
1.00 (referent) (N = 20)b |
2.45 (1.32–4.53) p = 0.004 (N = 21) |
1.00 (referent) (N = 11) |
2.08 (0.87–4.96) p = 0.10 (N = 15) |
1.00 (referent) (N = 9) |
4.00 (1.60–9.99) p = 0.003 (N = 6) |
| GSTM1 null |
1.83 (0.97–3.44) p = 0.06 (N = 24) |
2.48 (1.16–5.30) p = 0.02 (N = 11) |
1.84 (0.81–4.18) p = 0.14 (N = 11) |
2.88 (1.16–7.14) p = 0.02 (N = 9) |
2.04 (0.71–5.83) p = 0.19 (N = 13) |
1.49 (0.31–7.24) p = 0.62 (N = 2) |
| GSTT1 |
1.00 (referent) (N = 34) |
1.58 (0.93–2.70) p = 0.09 (N = 7) |
1.00 (referent) (N = 24) |
1.49 (0.78–2.87) p = 0.23 (N = 2) |
1.00 (referent) (N = 10) |
2.21 (0.86–5.64) p = 0.10 (N = 5) |
| GSTT1 null |
0.72 (0.32–1.64) p = 0.44 (N = 27) |
3.05 (1.38–6.72) p = 0.006 (N = 8) |
0.32 (0.08–1.35) p = 0.12 (N = 17) |
1.59 (0.45–5.67) p = 0.48 (N = 3) |
1.60 (0.53–4.80) p = 0.40 (N = 10) |
7.82 (2.49–24.50) p < 0.001 (N = 5) |
| GSTP1 Ile/Ile |
1.00 (referent) (N = 18) |
1.12 (0.48–2.63) p = 0.79 (N = 23) |
1.00 (referent) (N = 14) |
1.30 (0.50–3.43) p = 0.59 (N = 12) |
1.00 (referent) (N = 4) |
0.80 (0.14–4.52) p = 0.80 (N = 11) |
| GSTP1 Ile/Val or Val/Val |
0.68 (0.36–1.27) p = 0.22 (N = 8) |
1.68 (0.87–3.24) p = 0.12 (N = 27) |
0.50 (0.22–1.13) p = 0.09 (N = 6) |
1.13 (0.50–2.57) p = 0.77 (N = 14) |
0.84 (0.26–2.67) p = 0.76 (N = 2) |
3.68 (1.13–12.04) p = 0.03 (N = 13) |
| 0–1 High risk GST allelesa |
1.00 (referent) (N = 27) |
1.61 (0.88–2.96) p = 0.12 (N = 14) |
1.00 (referent) (N = 18) |
1.53 (0.70–3.35) p = 0.28 (N = 8) |
1.00 (referent) (N = 9) |
2.34 (0.88–6.22) p = 0.09 (N = 6) |
| 2–3 High risk GST alleles |
0.95 (0.49–1.82) p = 0.87 (N = 20) |
2.25 (1.22–4.53) p = 0.01 (N = 15) |
0.74 (0.31–1.74) p = 0.49 (N = 11) |
1.67 (0.73–3.85) p = 0.23 (N = 9) |
1.43 (0.50–4.05) p = 0.51 (N = 9) |
4.78 (1.58–14.43) p = 0.006 (N = 6) |
Hazard ratio (HR) and the 95% confidence interval (CI) adjusted for age, race, smoking, tumor stage and PSA at diagnosis
aThe number of high risk alleles refers to the total number of GST (GSTM1 null, GSTT1 null and GSTP1 105 Ile/Val or Val/Val) variants and individual carries (0, 1, 2 or 3)
bNumber of biochemical failure events (N) in each stratum