Table 5.
Risk of prostate cancer BCR after prostatectomy associated with GST polymorphisms by race and tumor aggressiveness status
| Genotype | Total sample | Caucasians | African-Americans | |||
|---|---|---|---|---|---|---|
| Low aggressive | High aggressive | Low aggressive | High aggressive | Low aggressive | High aggressive | |
| GSTM1 present |
1.00 (referent) (N = 15)b |
2.85 (1.52–5.34) p = 0.001 (N = 29) |
1.00 (referent) (N = 8) |
2.73 (1.13–6.56) p = 0.03 (N = 14) |
1.00 (referent) (N = 7) |
3.44 (1.37–8.65) p = 0.009 (N = 15) |
| GSTM1 null |
1.95 (0.96–4.00) p = 0.07 (N = 16) |
3.75 (1.85–7.61) p < 0.001 (N = 16) |
1.98 (0.76–5.14) p = 0.16 (N = 11) |
4.26 (1.73–10.48) p = 0.002 (N = 13) |
2.06 (0.64–6.62) p = 0.22 (N = 5) |
2.72 (0.70–10.61) p = 0.15 (N = 3) |
| GSTT1 present |
1.00 (referent) (N = 24) |
2.38 (1.42–4.01) p = 0.001 (N = 37) |
1.00 (referent) (N = 17) |
2.34 (1.25–4.38) p = 0.008 (N = 24) |
1.00 (referent) (N = 7) |
2.85 (1.10–7.43) p = 0.03 (N = 13) |
| GSTT1 null |
1.10 (0.48–2.56) p = 0.82 (N = 7) |
2.53 (1.13–5.64) p = 0.02 (N = 8) |
0.52 (0.12–2.26) p = 0.38 (N = 2) |
1.34 (0.39–4.62) p = 0.65 (N = 3) |
2.20 (0.69–6.97) p = 0.18 (N = 5) |
5.61 (1.72–18.36) p = 0.004 (N = 5) |
| GSTP1 Ile/Ile |
1.00 (referent) (N = 14) |
1.44 (0.66–3.15) p = 0.35 (N = 12) |
1.00 (referent) (N = 11) |
1.83 (0.75–4.48) p = 0.18 (N = 9) |
1.00 (referent) (N = 3) |
1.07 (0.21–3.04) p = 0.94 (N = 3) |
| GSTP1 Ile/Val or Val/Val |
0.62 (0.30–1.27) p = 0.19 (N = 17) |
1.92 (1.00–3.68) p = 0.05 (N = 33) |
0.49 (0.19–1.28) p = 0.14 (N = 8) |
1.56 (0.71–3.44) p = 0.27 (N = 18) |
0.82 (0.22–3.04) p = 0.77 (N = 9) |
3.01 (0.85–10.71) p = 0.09 (N = 15) |
| 0–1 High risk GST allelesa |
1.00 (referent) (N = 19) |
2.29 (1.27–4.12) p = 0.006 (N = 28) |
1.00 (referent) (N = 13) |
2.30 (1.10–4.80) p = 0.03 (N = 16) |
1.00 (referent) (N = 6) |
2.81 (1.02–7.76) p = 0.05 (N = 12) |
| 2–3 High risk GST allelesa |
1.20 (0.58–2.49) p = 0.62 (N = 12) |
3.00 (1.55–5.78) p = 0.001 (N = 17) |
0.90 (0.34–2.40) p = 0.83 (N = 6) |
2.29 (1.02–5.13) p = 0.05 (N = 11) |
1.87 (0.59–5.87) p = 0.29 (N = 6) |
5.14 (1.65–16.07) p = 0.005 (N = 6) |
High aggressive = High stage or high grade; Low aggressive = Low stage or low grade; Hazard ratio and 95% confidence interval adjusted for age, race, smoking and PSA at diagnosis
aThe number of high risk alleles refers to the number of GST (GSTM1 null, GSTT1 null and GSTP1 105 Ile/Val or Val/Val) variants carried
bNumber of biochemical failure events (N) in each stratum