Figure 8.

CF Bursts Enhance Long-Term Associative Plasticity of Purkinje Cells

(A) Responses of two Purkinje cells to the two plasticity induction protocols used: a burst (100 Hz) of five parallel fiber stimuli in conjunction with a single CF stimulus (left) or a burst (400 Hz) of CF stimuli (right; 25 repetitions at 0.5 Hz).

(B) Effect of the two induction protocols on PF synaptic strength (measured as normalized EPSP slope; mean ± SEM; CF burst: green symbols, n = 10; single CF stimulus: blue symbols; n = 9).

(C) Black traces: PF-EPSPs averaged over a minute before induction in two cells. Induction was performed with the single CF and the CF burst protocol in the top and bottom cell, respectively. The colored traces show the EPSPs 20 min after induction.

(D) Distribution of changes in PF synaptic strength 20 min after induction for all cells tested (CF burst: green symbols; single CF, blue symbols).