Table 1.

GS elements inserted within or adjacent to genes involved in oxidative stress modify the toxicity of Arctic Aβ

GS elements	Gene name	Gene identifier	Molecular function	GS insertion sites (range of sequence locations)
148, 174, 274, 1360, 2225, 2823, 3063	Lethal (2) 01289	CG9432	Thioredoxin-like domain	2252526–2252617
2703, 2521, 3102	Fer1HC and Fer2LC	CG2216 and CG1469	Iron chelator and ferroxidase activity	26215006–26215015
532, 1287, 1472.2, 1652, 2484	Fer1HC and Fer2LC	CG2216 and CG1469	Iron chelator and ferroxidase activity	26212564–26212784
811	Cyp6a20 Cytochrome P450-6a9	CG10245 and CG10246	Oxidoreductase activity in steroid metabolism	10396945
1264, 2155	Carbonyl reductase	CG11200	Reduction of aldehydes	15823515–15823522
1357	Orthologues of human retinol dehydrogenase	CG2064 and CG2065	Short chain dehydrogenases	20961357
1774	Orthologue of human aldehyde dehydrogenase 4A1 and Hsc70Cb	CG6661 and CG6603	Oxidation of aldehydes and chaperone	14029850–14036659

Aβ, β-amyloid peptide; GS, Gene Search.