Table 1.
Authors, year | Age (years) | Gender | Daily dose (mg) | Duration of PTU | Liver abnormality | Outcome |
---|---|---|---|---|---|---|
Moore, 1946 [8] | 12 | F | 300 | 0.5 months | Liver injury | Recovery |
Parker, 1975 [12] | 9 | F | 300 | 2 months | Portal inflammation cholestasis | Recovery |
Reddy, 1979 [14] | 10 | F | 300 | 1.2 months | Hepatitis | Recovery |
Bloch et al., 1985 [21] | 12 | M | 450 | 2 months | Hepatitis | Recovery |
Garty et al., 1985 [22] | 12 | F | 300 | 1 month | Hepatitis | Recovery |
Limaye and Ruffolo, 1987 [24] | 6 | F | 300 | 4 months | Hepatitis | Recovery |
Jonas and Eidson, 1988 [25] | 13 | F | 300 | 7 months | Massive necrosis | Death |
Baker et al., 1989 [26] | 9 | F | 300 | 3 months | Hepatitis | Recovery |
Kirkland, 1990 [29] | 9 | F | 300 | 4 months | Liver failure | Transplant/Recovery |
Levy, 1993 [31] | 11 | F | 300 | 14 months | Liver failure | Death |
Deidiker and deMello, 1996 [41] | 13 | F | 250 | 4 months | Liver failure | Transplant/Death |
Williams et al., 1997 [43] | 14 | F | 450 | 4 months | Liver failure | Transplant/Recovery |
Testa et al., 2003 [35] | 17 | F | 450 | 6 months | Liver failure | Transplant/Recovery |
Sipe et al., 2006 [37] | 7 | F | 300 | 9 months | Liver failure | Transplant/Recovery |