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Adverse events reported to the FDA from 1970 to 1997 in individuals ≤18 years of age.
| Adverse event | Propylthiouracil | Methimazole |
|---|---|---|
| Total number | 34 | 14 |
| Hospitalizations | 18 | 3 |
| Deaths | 2 | 0 |
| Liver injury: mild | 1 | 0 |
| Liver injury: serious | 13 | 0 |
| Liver transplantation | 2 | 0 |
| Liver injury-related death | 2 | 0 |
| Agranulocytosis | 1 | 1 |
| Leukopenia | 3 | 1 |
| Thrombocytopenia | 1 | 0 |
| Renal injury | 3 | 0 |
| Vasculitis | 3 | 1 |
| Arthritis | 1 | 2 |
| Arthralgia | 1 | 1 |
| Rash/urticaria | 5 | 9 |
