Table 3.

Pediatric cohort studies of propylthiouracil-related adverse events.

Authors, year	N	AE (n)	% AE	Adverse events
Hamburger, 1985 [57]	182	31	17%	11 Cutaneous
				1 Cutaneous and neutropenia
				1 Cutaneous and rheumatological
				1 Cutaneous and hepatic
				1 Cutaneous and pharyngitis
				4 Neutropenia
				2 Hepatic
				1 Rheumatological
				2 Nausea
				5 Multiple infections without neutropenia
				1 Unspecified
Lippe et al., 1987 [59]	63	1	1.5%	1 Arthritic reaction
Ward et al., 1999 [62]	33	8	24%	Rash, arthralgia, nausea, vomiting
Lazar et al., 2000 [63]	28	14	35%	2 Major; agranulocytosis; toxic hepatitis
				12 Minor
Somnuke et al., 2007 [61]	32	2	6%	ANCA; nephritis
				Rash, arthralgia
Glaser and Styne, 2008 [56]	70	11	16%	1 Rash
				2 Rash and arthralgia
				1 Arthritis with purpura
				1 Arthritis with purpura, hematuria
				3 Elevated liver function tests
				2 Marked elevated liver function tests
				2 Neutropenia
Ma et al., 2008 [60]	40	8	20%	6 Serious
	48	7	14.6%	NA