Figure 5.

Apo yeast Hsc82, human Hsp90α, and mouse Grp94 are distinct from bacterial HtpG in solution. The side view shown in the left column demonstrates a similar open angle for all homologs, whereas the eukaryotic homologs have a more distinctive bend in the NM domains. The second view is a 90° rotation of the first, and this top–down view shows that the Hsc82, Hsp90α, and Grp94 structures share the same CTD rotation and extended NM domain when compared with HtpG. These differences give the eukaryotic structures a chair-like shape instead of the linear structure seen for HtpG.