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. 2009 Sep;18(9):1815–1827. doi: 10.1002/pro.191

Figure 7.

Figure 7

AMPPNP has the largest effect on the conformation of Hsc82. (A) AMPPNP-bound Hsc82 (orange) is significantly more compact than apo Hsc82 (black). AMPPNP-bound Hsp90α (blue) is highly similar to apo Hsp90α (purple) and is best fit with the same mixture as apo Hsp90α. (B) AMPPNP-bound Hsc82 (orange) is best fit by a mixture (green) of 39% extended state, 56% yeast “ATP” crystal state, and 5% apo tetramer (R = 5.4%). (C) A comparison of apo Grp94 (gold) and AMPPNP-bound Grp94 (purple). (D) AMPPNP-bound Grp94 (purple) is fit with a mixture (green) of 58% extended state, 24% Grp94 crystal state, and 18% apo tetramer (R = 3.3%).