Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Visible circular dichroism spectra of wild-type ALAS and the R85 and R85/T430 variants. (A) wild-type ALAS, (B) R85K, (C) R85L, and (D) R85L/T430V. Spectra of the holoenzymes are in cyan. Spectra of the holoenzymes (100 μM) in the presence of 100 μM CoA derivative are indicated according to the following color scheme: pink, succinyl-CoA; green, octanoyl-CoA; blue, β-hydroxybutyryl-CoA; black, butyryl-CoA; and red, glutaryl-CoA.
