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. 2009 Dec 4;5(12):e1000751. doi: 10.1371/journal.pgen.1000751

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Deng et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A,B) Expression of PAR1 genes is similar between triploid and diploid cultures. (A) Average expression levels (± standard deviation) normalized to autosomal gene expression are shown in log₂ for nine PAR1genes [PLCXD1: phosphatidylinositol-specific phospholipase C, X domain containing 1; GTPBP6: GTP binding protein 6; SLC25A6:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6; CXYorf2: chromosome X and Y open reading frame 2; ASMTL: acetylserotonin O-methyltransferase-like; DHRSX: dehydrogenase/reductase (SDR family) X-linked; CD99: CD99 molecule; ZBED1: zinc finger, BED-type containing 1; SFRS17A: splicing factor, arginine/serine-rich 17A] in XaXaXi, XaXiXi, XYY triploid cultures, and in XaXi and XY diploid controls. (B) Average expression fold changes between triploid cultures with one or two Xa's and between female and male diploid cultures for nine PAR1 genes were not significantly different from 1.0 (p = 0.43, 0.29, 0.24, and 0.07 respectively; independent one-sample t-test, n = 9). (C) Cumulative expression of X- and Y-linked paralogs of XY gene pairs in human triploid and diploid cultures. Expression of the X- and Y-linked genes was normalized to autosomal gene expression. Stacked bars show the cumulative expression of X (solid bar) and Y paralogs (striped bar) in XaXaXi, XaXiXi, XYY triploid cultures, and XaXi and XY diploid controls. The X-linked paralogs are shown with (+) and (−) error bars in XXX and XX cell cultures and only with (−) error bars in XYY and XY cell cultures. The Y-linked paralogs are shown with (+) error bars. UTX/UTY: ubiquitously transcribed tetratricopeptide repeat, X chromosome/Y-linked; CXorf15/CYorf15A & B: chromosome X open reading frame 15/chromosome Y open reading frame 15A & chromosome Y open reading frame 15B; EIF1AX/EIF1AY: eukaryotic translation initiation factor 1A, X-linked/Y-linked; ZFX/ZFY: zinc finger protein, X-linked/Y-linked; DDX3X/DDX3Y: DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked/Y-linked; RPS4X/RPS4Y1:ribosomal protein S4, X-linked/Y-linked 1; USP9X/USP9Y: ubiquitin specific peptidase 9, X-linked/Y-linked; JARID1C/JARID1D: jumonji, AT rich interactive domain 1C/jumonji, AT rich interactive domain 1D; TMSB4X/TMSB4Y: thymosin beta 4, X-linked/Y-linked; TBL1X/TBL1Y: transducin (beta)-like 1X-linked/Y-linked.