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. 2009 Nov 25;4(11):e7994. doi: 10.1371/journal.pone.0007994

Table 3. The top 15 protein-sets from MSigDB C2 database for normal/tumor classification.

Pathway # Proteins # Corr Genes %Var FDR
HSA05211 RENAL CELL CARCINOMA 14 9 48 0.00041
HSA04540 GAP JUNCTION 10 6 44 0.0048
HSA04662 BCR SIG PATH 14 13 33 0.016
HSA04070 PHOSPHATIDYLINOSITOL SIGNALING 12 10 32 0.016
INTEGRIN MEDIATED CELL ADHESION GENMAPP 32 28 51 0.016
HSA05220 CHRONIC MYELOID LEUKEMIA 13 7 49 0.019
HSA05120 EPITHELIAL CELL SIGNALING HP INF 17 7 81 0.019
METPATHWAY BIOCARTA 24 20 55 0.019
HSA05223 NON SMALL CELL LUNG CANCER 12 6 52 0.019
ST DIFFERENTIATION PATHWAY IN PC12 CELLS 12 8 53 0.019
HSA05215 PROSTATE CANCER 13 6 52 0.019
HSA05218 MELANOMA 13 6 52 0.019
HSA05213 ENDOMETRIAL CANCER 13 6 52 0.019
HSA05210 COLORECTAL CANCER 14 8 50 0.019
HSA04010 MAPK SIGNALING PATHWAY 15 10 80 0.019

The protein-set name is listed in column 1. The number of proteins observed from that protein-set are reported in column 2. Column 3 reports the number of proteins within the protein-set that are most responsible for the differential phosphorylation of the metaprotein. Column 4 reports the percentage of the metaprotein's variation that is differential in tumor and normal tissue. Column 5 reports the FDR q-value measuring the significance of the differential phosphorylation of the metaprotein associated with the pathway in cancer.