Fig. 11.
Simulations of PMA effects on Kv4.3-S and Kv4.3-L. Simulations of peak current-voltage relationship (I-V; A and E), G/Gmax (B and F), steady-state inactivation (C and G), and closed-state inactivation (D and H) under experimental conditions described in Figs. 1, 2, and 4 are shown. PMA (10 nM) had no significant effects on simulations of peak I-V, G/Gmax, and steady-state inactivation. In contrast, PMA reduced the magnitude of closed-state inactivation in Kv4.3-S and increased the magnitude of closed-state inactivation in Kv4.3-L. These simulations closely reproduce the experimental data.