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. 2009 Aug 12;297(5):C1236–C1248. doi: 10.1152/ajpcell.00144.2009

Fig. 4.

Fig. 4.

Effects of PMA on closed-state inactivation of Kv4.3-S (A), Kv4.3-L (B), Kv4.3-L[T504A] (C), and Kv4.3-L[T504D] (D). Voltage-clamp protocol is described in Fig. 3 legend. Normalized peak current (P4/P1 currents), before and after exposure to 10 nM PMA, are plotted as a function of P3 pulse duration. Note that PMA had opposite effects on the magnitude of closed-state inactivation in Kv4.3-S and Kv4.3-L. The effects of PMA on Kv4.3-S and Kv4.3-L[T504A] were similar, and no effect on closed-state inactivation in Kv4.3-L[T504D] was observed.