Table 2.
Effects of PMA on recovery from closed- and open-state inactivation in Kv4.3-S and Kv4.3-L
| Vm, mV | Kv4.3-S Recovery τrec − CSI, ms | Kv4.3-L Recovery τrec − CSI, ms | Kv4.3-S Recovery τrec − OSI, ms | Kv4.3-L Recovery τrec − OSI, ms |
|---|---|---|---|---|
| −90 | ||||
| Control | 283±13 | 307±26 | ||
| PMA (10 nM) | 276±16 | 307±27 | ||
| −80 | ||||
| Control | 713±49 | 684±27 | ||
| PMA (10 nM) | 582±54# | 814±40# | ||
| −70 | ||||
| Control | 1,368±96 | 1,251±6 | ||
| PMA (10 nM) | 1,088±74# | 1,540±22# | ||
| −60 | ||||
| Control | 3,060±220 | 3,020±150 | ||
| PMA (10 nM) | 2,020±260# | 3,950±220# |
Values are means ± SE; n = 5 cells. Vm, voltage potential; τrec, time constant of recovery from inactivation.
#
P < 0.01 vs. control.