Figure 8.

Three-dimensional structure of the Top1-DNA binary complex. The protein subdomain I, subdomain II, subdomain III are rappresented in blue, yellow and red respectively, the linker in green and C-terminal in cyan. The lateral chain of the mutated Lys681 residue is represented in ball and stick and evidenced by a line. Nose cone helix 5 is also evidenced by a line (A). Representation of ten projections, in different colors, of the MD motions along the second eigenvector for the wild-type protein (B) and Lys681Ala mutant (C).