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. 2009 Sep 9;37(20):6701–6715. doi: 10.1093/nar/gkp727

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Changes in mtDNA methylation when TFAM levels are altered. Relative changes in methylation were determined in the following selected mtDNA regions: NCR (A), TERM (B) and OL (C). Changes were determined when TFAM was either overexpressed (upper part of panels) or down-regulated (lower part of panels). Methylation of mtDNA was determined as described in legend to Figure 4 and expressed as changes from the control.