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Time course of oxalate accumulation across the apical membrane (A) and basolateral membrane (B) for Con and A6KD monolayers in bicarbonate-free buffers. Apical uptake was determined with a Cl−-HCO3−-free mucosal buffer and a HCO3−-free serosal buffer, whereas the basolateral uptake measurements were made with the buffer compositions reversed. Each point represents the mean of 6–8 measurements and the error bars represent ±1 SE. *Significant difference between Con and A6KD.
