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Effects of NEM (10−4 M) on the inhibition of contraction induced by agonists. NEM blocked the effect of the exogenous inhibitor VIP (10−6 M) (#P < 0.001 by ANOVA) but had no effect on the inhibition of contraction induced by PGE2 (10−6 M) (an endogenous autacoid) and by 8B-cAMP (10−5 M) (receptor- and G protein-independent agonist). Values are means ± SE of n = 3.
