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A: GTPγS (10−4 M) increased the levels of PGF2α (*P < 0.02 by ANOVA). This increase was blocked by pretreating muscle cells with P4 (10−5 M) (**P < 0.02 by ANOVA). B: GDPβS (10−4 M) reduced the levels of PGF2α (#P < 0.01 by ANOVA). P4 (10−5 M) alone also reduced the levels of PGF2α (##P < 0.01 by ANOVA). However, the addition of GDPβS (10−4 M) to muscle cells pretreated with P4 had no additional effects (10−5 M). Values are means ± SE of n = 4.
