TABLE 6.
Summary of urine and serum biochemical measures at baseline and at the end of the 2 study periods1
| Baseline | Low-normal pH | High-normal pH | P value2 | |
| Final arterial pH | — | 7.37 ± 0.013 | 7.44 ± 0.02 | <0.001 |
| Urine volume (mL/d)4 | — | 16.9 (84.4)5 | 41.1 (335.3) | 0.03 |
| Urinary urea nitrogen (mg/d)4 | — | 15.3 (129.5) | 78.2 (668.3) | 0.25 |
| Urinary urea clearance (mL/min)4 | — | 0.02 (0.14) | 0.09 (1.02) | 0.03 |
| Urinary creatinine clearance (mL/min)4 | — | 0.08 (0.51) | 0.16 (1.4) | 0.35 |
| Urine protein excretion (mg/d)4 | — | 47 (143) | 148 (457) | 0.12 |
| Venous bicarbonate (mEq/L) | 23.0 ± 2.6 | 18.9 ± 2.2 | 24.6 ± 2.6 | 0.002 |
| Arterial pCO2 (mm Hg) | 37.5 ± 3.6 | 35.9 ± 3.0 | 41.8 ± 3.7 | 0.001 |
| Serum urea nitrogen (mg/dL) | 55.0 ± 17.1 | 64.4 ± 20.2 | 54.1 ± 13.7 | 0.01 |
| Serum creatinine (mg/dL) | 13.7 ± 4.6 | 13.6 ± 4.1 | 12.9 ± 3.5 | 0.18 |
| Serum potassium (mEq/L) | 4.2 ± 0.8 | 4.3 ± 0.7 | 3.9 ± 0.8 | 0.28 |
| Serum phosphorus (mg/dL) | 6.3 ± 1.8 | 5.7 ± 1.2 | 5.5 ± 1.1 | 0.48 |
| Serum parathyroid hormone (pg/mL)6 | 337 (273) | 224 (242) | 318 (252) | 0.21 |
| Serum albumin (g/dL)6 | 3.5 ± 0.6 | 3.1 ± 0.4 | 3.1 ± 0.4 | 0.12 |
| Serum prealbumin (g/dL) | 44.7 ± 10.6 | 40.7 ± 9.5 | 39.9 ± 7.5 | 0.72 |
| Serum transferrin (mg/dL) | 233.5 ± 57.8 | 206.6 ± 35.2 | 217.0 ± 73.8 | 0.57 |
| Serum insulin-like growth factor I (μg/L) | 192 (143) | 189 (173) | 159 (191) | 0.89 |
| Serum C-reactive protein (mg/L) | 3.2 ± 2.7 | 2.1 ± 1.4 | 1.8 ± 1.2 | 0.37 |
| Serum tumor necrosis factor (pg/mL) | 5.8 ± 1.7 | 6.4 ± 1.8 | 5.5 ± 1.3 | 0.09 |
| Serum interleukin-6 (pg/mL) | 3.8 ± 2.1 | 3.3 ± 1.8 | 2.6 ± 1.3 | 0.09 |
1
pCO2, partial pressure of carbon dioxide.
2
Significance of difference (end of low-normal and high-normal pH phases) between means tested by paired t test and between medians by Wilcoxon's signed-rank test.
3
Mean ± SD (all such values).
4
Values are the means for the last 5 d of each phase; 6 of the 8 study subjects had measurable urine outputs.
5
Median; interquartile range in parentheses (all such values).
6
Measured by using bromocresol purple during the inpatient phase of the study.