TABLE 8.

Summary of mRNA content in the quadriceps femoralis muscle of the 8 study subjects measured at the end of each study period¹

	Low-normal pH	High-normal pH	P value2
Final arterial pH	7.37 ± 0.013	7.44 ± 0.02	<0.001
Insulin-like growth factor IEa	20.5 (20.6)4	23.9 (23.3)	0.67
Insulin-like growth factor IEc	0.17 (0.24)	0.08 (0.15)	0.33
Insulin-like growth factor I receptor	10.8 (9.6)	13.0 (9.4)	0.67
Insulin-like growth factor II	256.7 (392.2)	192.6 (156.3)	0.67
Insulin-like growth factor II receptor	77.9 (79.0)	58.3 (43.7)	0.16
Insulin-like growth factor binding protein-2	66.8 (50.8)	67.2 (49.0)	0.89
Myostatin	127.2 (271.2)	47.1 (185.4)	0.07
MAFBx	133.1 (94.2)	85.5 (88.0)	0.40

¹MAFBx, muscle-specific ubiquitin ligase atrogin-1.

²Significance of difference between means tested by paired t test and between medians by Wilcoxon's signed-rank test.

³Mean ± SD (all such values).

⁴Median; interquartile range in parentheses (all such values).