TABLE 1.
Baseline anthropometric and biological characteristics for participants of the Boston Puerto Rican Health Study1
|
APOA5-1131T > C |
APOA5 S19W |
||||
|---|---|---|---|---|---|
| TT | TC+CC | CC | CG+GG | All participants | |
| n | 618 | 184 | 639 | 163 | 802 |
| Female, n (%) | 458 (74.1) | 129 (70.1) | 452 (70.7) | 135 (82.8)* | 587 (73.2) |
| Age, y | 57.9 ± 7.2 | 57.5 ± 7.1 | 57.9 ± 7.2 | 57.6 ± 7.2 | 57.8 ± 7.2 |
| BMI, kg/m2 | 32.2 ± 6.7 | 32.1 ± 7.0 | 32.0 ± 6.8 | 33.0 ± 6.6 | 32.2 ± 6.8 |
| Waist circumference, cm | 101.7 ± 15.1 | 101.8 ± 14.6 | 101.4 ± 15.0 | 103.2 ± 15.0 | 101.8 ± 15.0 |
| Physical activity score | 31.4 ± 4.5 | 32.0 ± 4.5 | 31.5 ± 4.5 | 31.8 ± 4.4 | 31.5 ± 4.5 |
| SBP, mm Hg | 136.2 ± 18.2 | 135.3 ± 19.7 | 136.1 ± 18.5 | 135.6 ± 19.0 | 136.0 ± 18.6 |
| DBP, mm Hg | 81.2 ± 10.6 | 80.7 ± 10.2 | 81.0 ± 10.5 | 81.5 ± 10.6 | 81.1 ± 10.5 |
| Biochemistry | |||||
| Serum glucose, mmol/L | 6.78 ± 2.69 | 6.69 ± 3.25 | 6.73 ± 2.88 | 6.87 ± 2.64 | 6.76 ± 2.83 |
| Plasma TG, mmol/L | 1.80 ± 1.23 | 1.95 ± 1.82 | 1.87 ± 1.49 | 1.71 ± 0.90 | 1.84 ± 1.39 |
| Plasma HDL-C, mmol/L | 1.16 ± 0.33 | 1.15 ± 0.33 | 1.17 ± 0.34 | 1.14 ± 0.29 | 1.16 ± 0.33 |
| Plasma LDL-C, mmol/L | 2.80 ± 0.84 | 2.73 ± 0.95 | 2.77 ± 0.91 | 2.81 ± 0.89 | 2.78 ± 0.90 |
| Plasma VLDL-C, mmol/L | 0.75 ± 0.38 | 0.79 ± 0.38 | 0.77 ± 0.39 | 0.74 ± 0.35 | 0.76 ± 0.38 |
| Plasma total cholesterol, mmol/L | 4.77 ± 1.09 | 4.70 ± 1.13 | 4.77 ± 1.11 | 4.70 ± 1.02 | 4.75 ± 1.10 |
| Energy intake, kJ/d | 9039 ± 3603 | 8938 ± 3859 | 8959 ± 3640 | 9239 ± 3744 | 9016 ± 3661 |
| Total fat, % energy | 31.1 ± 5.1 | 30.5 ± 5.6 | 30.9 ± 5.3 | 31.1 ± 5.1 | 52.0 ± 7.6 |
| Carbohydrate, % energy | 51.9 ± 7.3 | 52.3 ± 8.5 | 51.9 ± 7.7 | 52.4 ± 7.2 | 17.3 ± 3.5 |
| Protein, % energy | 17.2 ± 3.4 | 17.5 ± 3.6 | 17.3 ± 3.5 | 17.1 ± 7.2 | 31.0 ± 5.2 |
| European ancestry,2% | 56.9 ± 15.2 | 52.3 ± 8.5 | 57.3 ± 15.4 | 56.4 ± 14.6 | 27.4 ± 15.7 |
| African ancestry,2% | 27.7 ± 15.7 | 26.5 ± 15.8 | 27.2 ± 15.9 | 28.4 ± 14.9 | 57.1 ± 15.3 |
| Native American ancestry,2% | 15.4 ± 6.6 | 15.5 ± 6.7 | 15.5 ± 6.7 | 15.1 ± 6.1 | 15.4 ± 6.6 |
| Current smoker, % | 23.0 | 22.4 | 22.6 | 23.8 | 22.8 |
| Current drinker, % | 40.3 | 37.0 | 40.6 | 35.2 | 39.5 |
| Diabetes medication use, % | 32.6 | 36.6 | 34.4 | 30.2 | 33.5 |
| Hypertension medication use, % | 56.3 | 55.7 | 56.5 | 54.9 | 56.2 |
| Lipid-lowering medication use, % | 41.4 | 38.3 | 40.2 | 42.6 | 40.7 |
| MetS3 |
67.3 |
64.3 |
66.5 |
67.1 |
66.6 |
1
Values are mean ± SD or percent; n = 802. *Different from participants with CC genotype for APOA5 S19W, P < 0.05.
2
Expressed as the percent that each ancestral population contributes to total composition.
3
Three or more of the following conditions must be present: waist circumference ≥102 cm in men or ≥88 cm in women; fasting glucose ≥ 5.6 mmol/L; elevated blood pressure (SBP ≥ 130 or DBP ≥ 85 mm Hg); high TG (≥1.7 mmol/L); low HDL-C (<1.0 mmol/L in men or <1.3 mmol/L in women).