TABLE 2.
Association of APOA5 gene variants with markers of MetS in participants of the Boston Puerto Rican Health Study1
|
APOA5-1131T > C |
APOA5 S19W |
|||||
|---|---|---|---|---|---|---|
| TT | TC+CC | P-value | CC | CG+GG | P-value | |
| Waist circumference, cm | 101.7 ± 0.6 | 101.9 ± 1.1 | 0.863 | 101.3 ± 0.6 | 103.7 ± 1.2 | 0.064 |
| SBP, mm Hg | 136.1 ± 0.7 | 135.5 ± 1.4 | 0.721 | 135.9 ± 0.7 | 136.1 ± 1.5 | 0.929 |
| DBP, mm Hg | 81.9 ± 0.4 | 80.8 ± 0.8 | 0.702 | 81.0 ± 0.4 | 81.6 ± 0.8 | 0.554 |
| Serum glucose, mmol/L | 6.42 (6.29–6.55) | 6.23 (5.98–6.48) | 0.164 | 6.35 (6.23–6.48) | 6.55 (6.23–6.81) | 0.289 |
| Plasma TG, mmol/L | 1.56 (1.50–1.63) | 1.63 (1.50–1.74) | 0.387 | 1.58 (1.52–1.64) | 1.53 (1.41–1.66) | 0.485 |
| Plasma HDL-C, mmol/L | 1.17 ± 0.01 | 1.16 ± 0.02 | 0.859 | 1.18 ± 0.01 | 1.12 ± 0.03 | 0.044 |
| Plasma HDL-C (adjusted for TG), mmol/L | 1.17 ± 0.01 | 1.17 ± 0.02 | 0.847 | 1.18 ± 0.01 | 1.11 ± 0.02 | 0.012 |
| Plasma total cholesterol, mmol/L | 4.77 ± 0.04 | 4.74 ± 0.08 | 0.735 | 4.79 ± 0.04 | 4.67 ± 0.09 | 0.194 |
| Plasma LDL-C, mmol/L | 2.80 ± 0.04 | 2.74 ± 0.07 | 0.489 | 2.78 ± 0.04 | 2.79 ± 0.07 | 0.898 |
| Plasma VLDL-C, mmol/L |
0.67 (0.65–0.70) |
0.71 (0.66–0.76) |
0.195 |
0.69 (0.66–0.71) |
0.67 (0.63–0.72) |
0.721 |
1
Values are the estimated mean ± SE, or geometric mean (95% CI) for anti-log transformed measures for glucose, TG, and VLDL-C, n = 802. P-value shown for APOA5 polymorphism as main predictor, with adjustment for age, sex, smoking, alcohol intake, medication use (lipid-lowering, diabetes, and hypertension), population admixture, and BMI (or physical activity for waist circumference outcome).