TABLE 2.

Body and adipose tissue weights and plasma biochemistry of LDLR−/− and ob/ob;LDLR−/− mice fed high fat diets containing 6% olive oil or fish oil for 6 wk¹²

	LDLR−/−		ob/ob;LDLR−/−
Measurements	Olive Oil	Fish Oil	Olive Oil	Fish Oil
n (male/female)	19 (9/10)	20 (10/10)	5 (2/3)	7 (2/5)
Body weight, g	26.8 ± 1.3	27.9 ± 1.1	53.0 ± 1.0	52.7 ± 1.0
Perigonadal adipose tissue weight, g	0.66 ± 0.11	0.77 ± 0.09	3.40 ± 0.25	3.43 ± 0.19
Perigonadal adipose tissue weight, % body wt	2.25 ± 0.28	2.62 ± 0.23	6.39 ± 0.39	6.50 ± 0.35
TC, mg/dL	603 ± 36	476 ± 22†	2263 ± 116	2339 ± 104
TG, mg/dL	112 ± 13	70 ± 7†	445 ± 76	436 ± 30
NEFA, mmol/L	0.82 ± 0.06	0.56 ± 0.04‡	1.73 ± 0.22	1.93 ± 0.29
Glucose, mg/dL	117 ± 6	118 ± 5	115 ± 17	87 ± 10
Insulin, μg/L	0.92 ± 0.15	0.68 ± 0.09	4.86 ± 0.79	2.98 ± 0.35*
HOMA-IR	7.2 ± 1.4	5.2 ± 0.8	32.8 ± 7.9	16.0 ± 2.2*
Leptin, μg/L	13.6 ± 3.0	14.2 ± 2.2	n.d3	n.d.

¹Data are presented as mean ± SEM. *Different from corresponding olive oil ob/ob;LDLR−/−, P < 0.05; ^†different from corresponding olive oil LDLR−/−, P < 0.01; ^‡different from corresponding olive oil LDLR−/−, P < 0.001.

²To convert from mg/dL to mmol/L multiply by the following: 0.02586 for TC and 0.0113 for TG, to convert from mg/dL (glucose) to mmol/L, divide by 18, and to convert from μg/L (insulin) to pmol/L, multiply by 173.

³Assay not conducted.