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. 2009 Nov 25;4(11):e8035. doi: 10.1371/journal.pone.0008035

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Tiede et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–C) Immunohistochemical staining of 4µm paraffin sections of mammary glands from a 12-week-old luciferase transgenic mouse. Luciferase expressing MaSCs are observed in two locations: a basal position, indicated by red arrows, and a luminal position, indicated by black arrows. (D) Control staining of luciferase in non-transgenic mouse. (E,F) Staining of 3-week-old luciferase transgenic mouse mammary glands revealed an increased number of luciferase expressing MaSCs in terminal end buds. (G–I) Reconstituted glands from 1000 sorted CD24⁺CD29^hi P4 cells (G) singe GFP⁺ (H) or 500 GFP⁺ (I) sorted cells all showed that the luciferase expressing transplanted cells were found to differentiate into non-luciferase expressing cells as they reconstitute the gland. Scale bar in (A) represents 20µm. All panels in this figure use the same scale.