(A) Residues constituting subcavity IIa that are conserved among the four soybean lipoxygenases. The shape of subcavity IIa of VLX-B, linoleic acid (violet stick model), and iron (pink ball) are depicted. (B) The residues constituting the cavity IIa; conserved residues are represented by gray ball and sticks together with their van der Waal nets. The nonconserved residues were represented by stick model (VLX-B, orange; VLX-D, blue; LOX-1, green; LOX-3, cyan). (C) Internal cavity of VLX-B. The residues are represented in the same format as in (B).