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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Hear Res. 2009 May 10;255(1-2):33–43. doi: 10.1016/j.heares.2009.05.001

Figure 8.

Figure 8

Expression of GAP-43 in VCN (A) and DCN (B) after unilateral carboplatin treatment, as shown by the ipsilateral-to-contralateral (i:c) ratio of GAP-43 immunoreactivity. Animals surviving for 3 or 7 days showed ratios close to 1.0 in VCN as well as DCN and thus no difference between sides. At 15 and 31 days the ratio increased in VCN in all animals, demonstrating an increase of ipislateral GAP-43 expression. The difference in immuno-reactivity between sides were statistically analyzed and was found significant in all animals surviving for 15 or 31 days (grey bars; P < 0.05, paired t-test where matching ipsilateral and contralateral regions were paired) and highly significant (dark grey bars; P < 0.0001) in most of these animals. In DCN, the ratio between sides was close to 1.0 in all animals. Three animals, surviving for either 15 days or 31 days showed significant difference in GAP-43 expression (grey bars; P <0.05).