Table 3.
Diet Periodsa | |||||||
---|---|---|---|---|---|---|---|
GST-α, pg/ml | Ratiosb | ||||||
Genotype | Basalc | Single/ Basal |
Double/ Basal |
Double/ Single |
Single + Apiaceous/ Basal |
Single + Apiaceous/ Single |
Single + Apiaceous/ Double |
Overall | |||||||
Day 7 | 3433 ± 185 | 1.13 ± 0.07d | 1.14 ± 0.07d | 1.00 ± 0.06 | 1.00 ± 0.06 | 0.88 ± 0.05d | 0.88 ± 0.05d |
Day 11 | 3520 ± 190 | 1.11 ± 0.07 | 1.15 ± 0.07d | 1.03 ± 0.06 | 1.07 ± 0.07 | 0.96 ± 0.06 | 0.93 ± 0.06 |
Day 14 | 3488 ± 188 | 1.05 ± 0.06 | 1.11 ± 0.07 | 1.06 ± 0.06 | 1.01 ± 0.06 | 0.96 ± 0.06 | 0.90 ± 0.06 |
GSTM1+/GSTT1+ | |||||||
Day 7 | 3263 ± 265 | 1.00 ± 0.09 | 1.12 ± 0.10 | 1.11 ± 0.10 | 1.10 ± 0.10 | 1.09 ± 0.10 | 0.98 ± 0.09 |
Day 11 | 3081 ± 250 | 1.03 ± 0.09 | 1.23 ± 0.11d | 1.20 ± 0.11c | 1.11 ± 0.10 | 1.08 ± 0.09 | 0.90 ± 0.08 |
Day 14 | 3143 ± 255 | 1.03 ± 0.09 | 1.13 ± 0.10 | 1.09 ± 0.10 | 1.09 ± 0.10 | 1.06 ± 0.09 | 0.97 ± 0.09 |
GSTM1-null/GSTT1+ | |||||||
Day 7 | 3637 ± 278 | 0.96 ± 0.08 | 1.08 ± 0.09 | 1.12 ± 0.10 | 0.93 ± 0.08 | 0.97 ± 0.08 | 0.86 ± 0.07 |
Day 11 | 3550 ± 272 | 1.03 ± 0.09 | 0.99 ± 0.08 | 0.96 ± 0.08 | 1.01 ± 0.08 | 0.99 ± 0.08 | 1.03 ± 0.09 |
Day 14 | 3319 ± 257 | 1.07 ± 0.09 | 1.15 ± 0.10 | 1.08 ± 0.09 | 1.05 ± 0.09 | 0.98 ± 0.08 | 0.91 ± 0.08 |
GSTM1-null/GSTT1-null | |||||||
Day 7 | 3409 ± 402 | 1.50 ± 0.19d | 1.21 ± 0.17 | 0.81 ± 0.11 | 0.97 ± 0.14 | 0.65 ± 0.09d | 0.80 ± 0.12 |
Day 11 | 3989 ± 470 | 1.31 ± 0.17d | 1.25 ± 0.17 | 0.96 ± 0.13 | 1.09 ± 0.15 | 0.84 ± 0.12 | 0.88 ± 0.13 |
Day 14 | 4068 ± 480 | 1.06 ± 0.14 | 1.07 ± 0.15 | 1.01 ± 0.14 | 0.89 ± 0.13 | 0.84 ± 0.12 | 0.83 ± 0.12 |
Basal = fruit/vegetable-free; Single = single-dose cruciferous; double = double-dose cruciferous; all vegetable diets adjusted per kg BW.
The difference of the back-transformed LS-means between diets as indicated.
LS-means ± SE, adjusted for baseline and feeding period day 0 serum GST-α concentrations.
Significantly different at P<0.05.