Table 3. HIV protein-specific CD8 responses and rates of CD4 decline: Bi-Variate anlayses.
In the primary analysis (where individuals are classified as “nonresponder” and “responder” if they responded to 0 or ≥1 peptide within the indicated protein), results are expressed in terms of absolute rates of CD4 decline (cells/mm3 per year) for each category. In the secondary analysis (where biomarkers are treated as continuous variables), results are expressed in terms of the difference in rate of CD4 decline (cells/mm3 per year) per every indicated increment in the biomarker. For example, every per-unit increment in the absolute breadth of Gag p24 responses is associated with a difference in rate of CD4 decline of +0.44 cells/mm3 per year.
| Biomarker | Group | Frequency (%) | CD4 cell decline (cells/mm3 per year) | p-value |
|---|---|---|---|---|
| Primary Analysis: responder vs. nonresponder | ||||
| p24Gag | nonresponder | 68 (23) | −33.3 | 0.77 |
| responder | 232 (77) | −34.7 | ||
| Pol | nonresponder | 56 (19) | −36.4 | 0.65 |
| responder | 244 (81) | −34.1 | ||
| Env | nonresponder | 173 (58) | −36.6 | 0.18 |
| responder | 127 (42) | −32.1 | ||
| Acc/Reg | nonresponder | 37 (12) | −35.4 | 0.84 |
| responder | 263 (88) | −34.3 | ||
| Secondary Analyses: CD8 responses as continuous variables | ||||
|---|---|---|---|---|
| Difference in rate of CD4 decline cells/mm3 per year, per indicated increment in biomarker (SE*) | p-value | |||
| Absolute Breadth (per unit increment) | ||||
| p24Gag | 0.44 (1.0) | 0.65 | ||
| Pol | 0.98 (0.8) | 0.24 | ||
| Env | 0.98 (1.8) | 0.58 | ||
| Acc/Reg | 0.42 (0.8) | 0.61 | ||
| Relative Breadth (per 10% increment) | ||||
| p24Gag | −0.01 (0.83) | 0.99 | ||
| Pol | 1.0 (0.9) | 0.26 | ||
| Env | 2.2 (1.6) | 0.2 | ||
| Acc/Reg | 0.2 (1.0) | 0.84 | ||
| Magnitude (per increment of 100 SFC/million) | ||||
| p24Gag | 0.2 (0.1) | 0.05 | ||
| Pol | 0.1 (0.1) | 0.09 | ||
| Env | 0.3 (0.2) | 0.29 | ||
| Acc/Reg | 0.1 (0.1) | 0.15 | ||
*
SE= standard error