Table II.

Activity for Aplidin against the PPTP in Vivo Panel

Xenograft Line	Histology	P-value	EFS T/C	Median Final RTV	Tumor Volume T/C	P-value	T/C Activity	EFS Activity	Response Activity
BT-29	Rhabdoid	0.009	1.4	>4	0.52	0.002	Low	Low	Low
KT-14	Rhabdoid	0.33	1.5	>4	0.9	0.36	Low	Low	Low
KT-12	Rhabdoid	0.406	1.1	>4	0.82	0.274	Low	Low	Low
KT-10	Wilms	0.259	1.2	>4	0.64	0.043	Low	Low	Low
KT-11	Wilms	0.104	1.3	>4	0.71	0.105	Low	Low	Low
KT-13	Wilms	0.048	1.2	>4	0.83	0.113	Low	Low	Low
SK-NEP-1	Ewing	0.224	1.2	>4	0.82	0.19	Low	Low	Low
CHLA258	Ewing	0.825	1	>4	0.79	0.631	Low	Low	Low
Rh28	ALV RMS	0.831	1.3	>4	0.75	0.573	Low	Low	Low
Rh30	ALV RMS	0.19	0.8	>4	1.03	0.971	Low	Low	Low
Rh30R	ALV RMS	0.26	1.1	>4	0.9	0.258	Low	Low	Low
Rh41	ALV RMS	0.025	1.1	>4	0.79	0.094	Low	Low	Low
Rh65	ALV RMS	0.16	1.4	>4	0.86	0.631	Low	Low	Low
Rh18	EMB RMS	0.002	1.5	>4	0.58	0.001	Low	Low	Int
BT-45	Medulloblastoma	0.033	1.4	>4	0.76	0.237	Low	Low	Low
BT-41	Ependymoma	0.549	0.9	>4	0.97	0.867	Low	Low	Low
GBM2	Glioblastoma	<0.001	1.5	>4	0.67	0.019	Low	Low	Low
D456	Glioblastoma	0.106	1.2	>4	0.79	0.093	Low	Low	Low
NB-SD	Neuroblastoma	0.007	1.4	>4	0.53	<0.001	Low	Low	Low
NB-1771	Neuroblastoma	0.004	1.4	>4	0.75	0.075	Low	Low	Low
NB-EBc1	Neuroblastoma	0.016	1.4	>4	0.72	0.579	Low	Low	Low
NB-1643	Neuroblastoma	0.152	1.1	>4	0.74	0.075	Low	Low	Low
OS-1	Osteosarcoma	<0.001	1.2	>4	0.65	<0.001	Low	Low	Low
OS-2	Osteosarcoma	0.698	1.1	>4	0.9	0.529	Low	Low	Low
OS-17	Osteosarcoma	0.029	1.2	>4	0.71	0.105	Low	Low	Low
OS-9	Osteosarcoma	0.201	1.3	>4	0.71	0.028	Low	Low	Low
OS-33	Osteosarcoma	0.127	1	>4	0.74	0.247	Low	Low	Low
OS-31	Osteosarcoma	<0.001	1.2	>4	0.63	0.003	Low	Low	Low
ALL-2	ALL B-precursor	0.818	1.5	>25	.			Low	Int
ALL-3	ALL B-precursor	0.041	11.2	>25	.			Int	Int
ALL-4	ALL B-precursor	0.371	2.1	>25	.			Low	Int
ALL-7	ALL B-precursor	0.707	1.4	>25	.			Low	Low
ALL-8	ALL T-cell	0.001	4.7	>25	.			Int	Int
ALL-19	ALL B-precursor	0.703	3.4	>25	.			Low	Int