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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Pediatr Blood Cancer. 2009 Sep;53(3):509–512. doi: 10.1002/pbc.21976

Table II.

Activity for Aplidin against the PPTP in Vivo Panel

Xenograft Line Histology P-value EFS T/C Median Final RTV Tumor Volume T/C P-value T/C Activity EFS Activity Response Activity
BT-29 Rhabdoid 0.009 1.4 >4 0.52 0.002 Low Low Low
KT-14 Rhabdoid 0.33 1.5 >4 0.9 0.36 Low Low Low
KT-12 Rhabdoid 0.406 1.1 >4 0.82 0.274 Low Low Low
KT-10 Wilms 0.259 1.2 >4 0.64 0.043 Low Low Low
KT-11 Wilms 0.104 1.3 >4 0.71 0.105 Low Low Low
KT-13 Wilms 0.048 1.2 >4 0.83 0.113 Low Low Low
SK-NEP-1 Ewing 0.224 1.2 >4 0.82 0.19 Low Low Low
CHLA258 Ewing 0.825 1 >4 0.79 0.631 Low Low Low
Rh28 ALV RMS 0.831 1.3 >4 0.75 0.573 Low Low Low
Rh30 ALV RMS 0.19 0.8 >4 1.03 0.971 Low Low Low
Rh30R ALV RMS 0.26 1.1 >4 0.9 0.258 Low Low Low
Rh41 ALV RMS 0.025 1.1 >4 0.79 0.094 Low Low Low
Rh65 ALV RMS 0.16 1.4 >4 0.86 0.631 Low Low Low
Rh18 EMB RMS 0.002 1.5 >4 0.58 0.001 Low Low Int
BT-45 Medulloblastoma 0.033 1.4 >4 0.76 0.237 Low Low Low
BT-41 Ependymoma 0.549 0.9 >4 0.97 0.867 Low Low Low
GBM2 Glioblastoma <0.001 1.5 >4 0.67 0.019 Low Low Low
D456 Glioblastoma 0.106 1.2 >4 0.79 0.093 Low Low Low
NB-SD Neuroblastoma 0.007 1.4 >4 0.53 <0.001 Low Low Low
NB-1771 Neuroblastoma 0.004 1.4 >4 0.75 0.075 Low Low Low
NB-EBc1 Neuroblastoma 0.016 1.4 >4 0.72 0.579 Low Low Low
NB-1643 Neuroblastoma 0.152 1.1 >4 0.74 0.075 Low Low Low
OS-1 Osteosarcoma <0.001 1.2 >4 0.65 <0.001 Low Low Low
OS-2 Osteosarcoma 0.698 1.1 >4 0.9 0.529 Low Low Low
OS-17 Osteosarcoma 0.029 1.2 >4 0.71 0.105 Low Low Low
OS-9 Osteosarcoma 0.201 1.3 >4 0.71 0.028 Low Low Low
OS-33 Osteosarcoma 0.127 1 >4 0.74 0.247 Low Low Low
OS-31 Osteosarcoma <0.001 1.2 >4 0.63 0.003 Low Low Low
ALL-2 ALL B-precursor 0.818 1.5 >25 . Low Int
ALL-3 ALL B-precursor 0.041 11.2 >25 . Int Int
ALL-4 ALL B-precursor 0.371 2.1 >25 . Low Int
ALL-7 ALL B-precursor 0.707 1.4 >25 . Low Low
ALL-8 ALL T-cell 0.001 4.7 >25 . Int Int
ALL-19 ALL B-precursor 0.703 3.4 >25 . Low Int