Table 2.
Model A Age and sex adjusted |
Model B* Plus MI history excluded |
Model C† Plus adjustment for vascular risk factors |
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Measure | Study | Sample n |
Beta (95% CI) | p- value |
Beta (95% CI) | p-value | Beta (95% CI) | p-value |
Ankle-Brachial Index (ABI Units) |
InChianti | 804 | −0.024 (−0.04, −0.005) | 0.012 | −0.020 (−0.04, −0.00) | 0.036 | −0.019 (−0.04, −0.001) | 0.038 |
Health ABC | 1569 | −0.022 (−0.03, −0.01) | 1.6×10−4 | −0.020 (−0.03, −0.01) | 8.1*10−4 | −0.017 (−0.03, −0.006) | 0.002 | |
BLSA§ | 257 | −0.002 (−0.03, 0.02) | 0.867 | 0.003 (−0.02, 0.03) | 0.842 | −0.0007 (−0.03, 0.03) | 0.958 | |
Meta-Analysis | 2630 | −0.020 (−0.03, −0.01) | 1.1*10−5 | −0.017 (−0.03, −0.01) | 1.3×10−4 | −0.016 (−0.03, −0.01) | 1.7×10−4 | |
Measure | Study |
n cases/ controls |
Odds Ratio (95% CI) |
p-value |
Odds Ratio (95% I) |
p-value |
Odds Ratio (95% CI) |
p-value |
Peripheral Artery Disease‡ |
InChianti | 107/697 | 1.35 (0.99, 1.83) | 0.054 | 1.33 (0.96, 1.85) | 0.087 | 1.37 (0.97, 1.94) | 0.077 |
Health ABC | 148/1421 | 1.42 (1.11, 1.82) | 0.005 | 1.36 (1.05, 1.76) | 0.019 | 1.33 (1.01, 1.75) | 0.042 | |
BLSA§ | 18/239 | 0.83 (0.41, 1.69) | 0.613 | 0.66 (0.31, 1.42) | 0.292 | 0.58 (0.26, 1.30) | 0.185 | |
Meta-analysis | 273/2357 | 1.34 (1.12, 1.62) | 0.002 | 1.29 (1.06, 1.57) | 0.012 | 1.27 (1.03, 1.57) | 0.024 |
Estimates adjusted for age and sex, following removal of participants with definite or possible MI at baseline and/or within 6 year follow-up period.
Estimates adjusted for age, sex, current or former smokers, Diabetes Mellitus, hypercholesterolemia and hypertension following removal of participants with MI at baseline and within 6 year follow-up period.
PAD defined as ABI less than or equal to 0.90.
rs4977574 used in analysis as a proxy for rs1333049 r20.9