Table 2.

Per risk allele (‘C’) linear regression based associations between rs1333049 status and ankle-brachial index, plus logistic regression based associations with peripheral arterial disease.

			Model A Age and sex adjusted		Model B* Plus MI history excluded		Model C† Plus adjustment for vascular risk factors
Measure	Study	Sample n	Beta (95% CI)	p- value	Beta (95% CI)	p-value	Beta (95% CI)	p-value
Ankle-Brachial Index (ABI Units)	InChianti	804	−0.024 (−0.04, −0.005)	0.012	−0.020 (−0.04, −0.00)	0.036	−0.019 (−0.04, −0.001)	0.038
	Health ABC	1569	−0.022 (−0.03, −0.01)	1.6×10−4	−0.020 (−0.03, −0.01)	8.1*10−4	−0.017 (−0.03, −0.006)	0.002
	BLSA§	257	−0.002 (−0.03, 0.02)	0.867	0.003 (−0.02, 0.03)	0.842	−0.0007 (−0.03, 0.03)	0.958
	Meta-Analysis	2630	−0.020 (−0.03, −0.01)	1.1*10−5	−0.017 (−0.03, −0.01)	1.3×10−4	−0.016 (−0.03, −0.01)	1.7×10−4
Measure	Study	n cases/ controls	Odds Ratio (95% CI)	p-value	Odds Ratio (95% I)	p-value	Odds Ratio (95% CI)	p-value
Peripheral Artery Disease‡	InChianti	107/697	1.35 (0.99, 1.83)	0.054	1.33 (0.96, 1.85)	0.087	1.37 (0.97, 1.94)	0.077
	Health ABC	148/1421	1.42 (1.11, 1.82)	0.005	1.36 (1.05, 1.76)	0.019	1.33 (1.01, 1.75)	0.042
	BLSA§	18/239	0.83 (0.41, 1.69)	0.613	0.66 (0.31, 1.42)	0.292	0.58 (0.26, 1.30)	0.185
	Meta-analysis	273/2357	1.34 (1.12, 1.62)	0.002	1.29 (1.06, 1.57)	0.012	1.27 (1.03, 1.57)	0.024

^*Estimates adjusted for age and sex, following removal of participants with definite or possible MI at baseline and/or within 6 year follow-up period.

^†Estimates adjusted for age, sex, current or former smokers, Diabetes Mellitus, hypercholesterolemia and hypertension following removal of participants with MI at baseline and within 6 year follow-up period.

^‡PAD defined as ABI less than or equal to 0.90.

^§rs4977574 used in analysis as a proxy for rs1333049 r²0.9