Figure 1.

A, structures of the peptoid submonomers that were used to construct the library. Submonomers 2 and 4 were protected during synthesis with t-Butoxycarbonyl (Boc), and 7 with 2,2,5,7,8-pentamethyl-chromane-6-sulfonyl (PMC); protecting groups were removed upon cleavage from the resin. B, the general structure of the peptoid library that was synthesized. C, the Huisgen dipolar cycloaddition reaction that was used to anchor azide-displaying peptoids onto alkyne-functionalized agarose (R⁵= agarose) or to conjugate to propargylamine (R⁵ = H) for testing inhibition of self-splicing. Unless indicated, the compounds tested for inhibition of self-splicing contained a triazole.