Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Structure-based analyses of 4-4-3-12 and 4-4-2-12 for inhibition of precursor self-splicing. Submonomers were either sequentially deleted or replaced with 11.
| Sequence R1,R2,R3 | IC50 (µM) |
|---|---|
| 4-4-3-12 | 158 ± 14 |
| 4-4-3-10 | 533 ± 58 |
| 4-4-3 | 633 ± 153 |
| 4-4-2-12 | 97 ± 49 |
| 4-4-2-10 | 338 ± 88 |
| 4-4 | 733 ± 115 |
| 3 | >5,000 |
| 11-4-3-12 | >5,000 |
| 4-11-3-12 | 1,333 ± 144 |
| 11-4-2-12 | 1,083 ± 227 |
| 4-11-2-12 | 1,233 ± 252 |
| 4-4-11-12 | 767 ± 153 |
| TBTA | >5,000 |
