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. Author manuscript; available in PMC: 2009 Nov 16.
Published in final edited form as: Prostate. 2002 Oct 1;53(2):143–153. doi: 10.1002/pros.10141

Fig 2.

Fig 2

Effects of soy components on apoptosis index (A), proliferation index (B), and the expression of p53 (C,D) in primary prostate tumors in mice. Primary tumors were determined for tumor cell apoptosis by the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay and proliferation by proliferating cell nuclear antigen staining. The expression ofp53 was determined by immunohistochemistry and quantified by image analysis. Dietary supplements of soy protein, genistin, and soy phytochemical concentrate (SPC) significantly increased tumor cell apoptosis but nonsignificantly reduced tumor cell proliferation index. Dietary supplement of SPC significantly up-regulated the expression of p53.In SPC-treated mice, p53-positive tumor cells had increased staining intensity in the nuclei. Values represent mean ± SEM. Asterisks indicate P at least <0.05 compared with the control.