Table 1.

General characteristics of R+A+ mouse model

Variants	R−A−	R+A+
Body weight, g	28±2	27±3
Heart weight/body weight, mg/g	3.7±0.3	5.9±0.3*
Mean arterial pressure, mmHg	98±3	128±4*
Heart rate, beats/min	565±25	581±32
Plasma ANG II level, pg/ml	78±34	227±53*
Brain ANG II level, fmol/mg	36±12	114±25*

Data are expressed as means ± SE; n = 5–6 mice/group. R+A+, mice overexpressing renin and angiotensinogen; R−A−, wild-type control animals.

^*P < 0.01, compared with R−A−.