A: segments of original recordings from an individual sham-operated rat and a rat with heart failure (HF), demonstrating the representative response to HR, mean arterial pressure (MAP), integrated renal sympathetic nerve activity (int. RSNA) and RSNA to the microinjections (arrows) of ANG II into the PVN. B: mean data of changes in HR, MAP, and RSNA after microinjections of ANG II and artificial cerebrospinal fluid (aCSF) into the PVN and intravenous injections in sham and HF rats. *P < 0.05 vs. group of sham.