Fig. 2.

Top: body weight in rats after administration of control vector or high-dose rAAV antagonist. rAAV antagonist or control vectors were administered at day 0 in rats maintained on a chow diet for 82 days. After a series of tests and blood draw, the rats were switched to a 60% high-fat (HF) diet until day 140, after which they were returned to the chow diet for the remainder of the experiment. WR indicates days on which wheel running was evaluated. Values represent means ± SE of 5 rats/group. Bottom: change (Δ) in body weight over the indicated days, representing the initial chow feeding period after recovery from surgery and before blood draw (left), the HF feeding period before evaluation of WR (center), and the final chow feeding period before evaluation of WR (right). *P = 0.0005, difference from control by t-test.