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. 2009 Sep 2;297(5):R1254–R1261. doi: 10.1152/ajpregu.90449.2008

Fig. 5.

Fig. 5.

Top: WR activity during chow and HF feeding periods in rats after administration of control vector or rAAV-leptin antagonist. WR was assessed for a 4-day period during chow feeding after the low dose of the antagonist vector (days 34–38) and during HF feeding (days 130–134) and chow feeding (days 184–188) after the high dose of antagonist vector. Values represent means ± SE of 5 or 6 rats/group. *P = 0.001, difference with antagonist treatment; **P = 0.03, difference between control chow-fed and control HF-fed rats after high dose of antagonist vector. Bottom: WR activity after administration of control vector, rAAV-leptin, or control vector pair fed the amount of food consumed by the rAAV-leptin group. WR was assessed for a 4-day period starting at day 105 after vector delivery. Values represent means ± SE of 8–10 rats/group. *P = 0.001 for difference with leptin treatment from control or pair fed by 1-way ANOVA.