Relative changes in mean arterial pressure (MAP) from baseline after infusion of PolybHb. A: PolybHb fractions with molecular mass <500 kDa. Baseline MAP values (mmHg) for each group were as follows: PolybHb(20:1), 110 ± 9; PolybHb(30:1), 113 ± 7; PolybHb(40:1), 107 ± 8; PolybHb(50:1), 111 ± 9. B: PolybHb fractions with molecular mass >500 kDa. Baseline MAP values (mmHg) for each group were as follows: PolybHb(20:1), 107 ± 8; PolybHb(30:1), 110 ± 8; PolybHb(40:1), 108 ± 10; PolybHb(50:1), 112 ± 8. BL, baseline level (broken line). Values are means ± SD. †P < 0.05 relative to baseline. #P < 0.05 compared with PolybHb(50:1).