Table 2.
Absolute values for MAP, HR, Hct, Hb, and body weight at baseline
| <500 kDa |
>500 kDa |
|||||||
|---|---|---|---|---|---|---|---|---|
| 20:1 PolybHb(20:1)low | 30:1 PolybHb(30:1)low | 40:1 PolybHb(40:1)low | 50:1 PolybHb(50:1)low | 20:1 PolybHb(20:1)high | 30:1 PolybHb(30:1)high | 40:1 PolybHb(40:1)high | 50:1 PolybHb(50:1)high | |
| Baseline | ||||||||
| n | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| MAP, mmHg | 110±9 | 113±7 | 107±8 | 111±9 | 107±8 | 110±8 | 108±10 | 112±8 |
| HR, beats/min | 424±22 | 427±18 | 431±23 | 423±19 | 430±24 | 437±25 | 422±24 | 440±24 |
| Hct, % | 49±2 | 48±2 | 48±2 | 49±1 | 49±2 | 48±2 | 49±2 | 48±1 |
| Hb, g/dl | 15.2±0.8 | 14.8±0.7 | 15.1±1.0 | 15.2±0.5 | 15.0±0.8 | 14.7±0.6 | 14.9±0.8 | 14.7±0.8 |
| Body weight, g | 67.6±4.9 | 65.9±4.6 | 68.4±6.4 | 67.3±6.3 | 66.1±4.7 | 64.4±4.1 | 63.4±4.2 | 68.1±3.8 |
| Plasma concentration 0.5 g/dl | ||||||||
| Volume infused, ml | 0.13±0.06 | 0.13±0.04 | 0.23±0.08* | 0.30±0.14* | 0.13±0.05 | 0.12±0.06 | 0.12±0.03 | 0.13±0.05 |
| Hct, % | 46±1 | 46±2 | 45±2 | 47±1 | 47±1 | 47±2 | 48±1 | 48±1 |
| HbTotal, g/dl | 14.8±0.7 | 14.6±0.6 | 14.7±0.8 | 14.6±0.6 | 14.7±0.7 | 14.6±0.5 | 14.8±0.6 | 14.8±0.6 |
| Hbplasma, g/dl | 0.4±0.1 | 0.5±0.1 | 0.4±0.1 | 0.5±0.2 | 0.5±0.1 | 0.4±0.1 | 0.5±0.1 | 0.5±0.1 |
| Plasma concentration 1.0 g/dl | ||||||||
| Volume infused, ml | 0.28±0.11 | 0.27±0.09 | 0.47±0.11* | 0.62±0.21* | 0.26±0.09 | 0.26±0.07 | 0.25±0.09 | 0.26±0.09 |
| Hct, % | 43±2 | 43±2 | 42±2 | 42±1 | 45±2 | 43±2 | 46±1 | 46±1 |
| HbTotal, g/dl | 14.7±0.6 | 14.8±0.7 | 15.2±0.7 | 15.1±0.5 | 15.0±0.6 | 14.8±0.6 | 15.2±0.5 | 15.3±0.6 |
| Hbplasma, g/dl | 0.9±0.1 | 1.0±0.1 | 0.9±0.1 | 0.9±0.1 | 0.9±0.1 | 0.9±0.1 | 1.0±0.1 | 0.9±0.1 |
| Plasma concentration 1.5 g/dl | ||||||||
| Volume infused, ml | 0.42±0.12 | 0.40±0.10 | 0.72±0.17* | 0.92±0.22* | 0.45±0.16 | 0.49±0.15 | 0.40±0.09 | 0.41±0.09 |
| Hct, % | 43±1 | 43±1 | 40±2 | 40±1 | 45±1 | 43±1 | 45±1 | 45±1 |
| HbTotal, g/dl | 15.3±0.5 | 15.3±0.4 | 15.3±0.5 | 15.6±0.4 | 15.8±0.5 | 15.7±0.6 | 15.9±0.5 | 16.0±0.5 |
| Hbplasma, g/dl | 1.4±0.2 | 1.4±0.1 | 1.4±0.1 | 1.5±0.2 | 1.4±0.1 | 1.4±0.2 | 1.5±0.1 | 1.5±0.1 |
| Blood viscosity, cp | 3.7±0.2 | 3.7±0.2 | 3.5±0.2 | 3.5±0.1 | 3.8±0.1 | 3.8±0.2 | 4.4±0.2 | 5.0±0.3 |
| Plasma viscosity, cp | 1.1±0.1 | 1.1±0.1 | 1.2±0.1 | 1.2±0.1 | 1.1±0.2 | 1.2±0.1 | 1.6±0.2* | 2.0±0.2* |
Values are means ± SE for mean arterial blood pressure (MAP), heart rate (HR), hematocrit (Hct), hemoglobin (Hb), and body weight at baseline and various PolybHb plasma concentrations; n = no. of animals per group.
*
P < 0.05 compared with 20:1 and 30:1.