Table 1.
Nicotine dose and steady-state concentrations (ng/ml) of nicotine and cotinine in maternal and fetal plasma
| Animal No. | Nicotine Dose, mg·day−1·kg−1 | Nicotine, ng/ml |
Cotinine, ng/ml |
Fetal-to-Maternal Ratio |
|||
|---|---|---|---|---|---|---|---|
| Mother | Fetus | Mother | Fetus | Nicotine | Cotinine | ||
| 1 | 0.90 | 15.6 | 13.0 | 163 | 150 | 0.83 | 0.92 |
| 2 | 0.86 | 21.2 | 19.1 | 202 | 149 | 0.90 | 0.74 |
| 3 | 0.73 | 11.4 | 15.4 | 139 | 138 | 1.35 | 1.00 |
| 4 | 0.65 | 10.9 | 10.9 | 146 | 148 | 1.00 | 1.01 |
| 5 | 0.64 | 13.2 | 11.1 | 180 | 183 | 0.84 | 1.01 |
| Mean ± SE | 0.76±0.04 | 14.4±1.9 | 13.9±1.5 | 166±12 | 154±8 | 0.99±0.09 | 0.94±0.50 |