Table 2.
Growth measurements of the nicotine-exposed fetal baboons compared with controls
| Measure | Control Fetuses | Nicotine-Exposed Fetuses | Unadjusted P Value | FDR Corrected P Value | FDR Corrected P Value* |
|---|---|---|---|---|---|
| n | 6 | 5 | 5 controls | ||
| Postconceptional age (age at sacrifice), days | 161.70±1.15 | 160.20±2.04 | 0.53 | 0.74 | 0.74 |
| Placental weight, g | 265.50±28.89 | 230.40±9.17 | 0.29 | 0.73 | 0.74 |
| Maternal weight, kg | 16.93±1.18 | 16.21±1.12 | 0.67 | 0.74 | 0.93 |
| Fetal brain weight, g | 58.62±5.13 | 73.50±2.76 | 0.05 | 0.35 | 0.35 |
| Fetal weight, g | 680.40±50.26 | 629.80±26.78 | 0.43 | 0.74 | 0.74 |
| Fetal brain-to-body weight ratio | 0.09±0.01 | 0.11±<0.01 | 0.07† | 0.35 | 0.35 |
| Fetal body-to-placental weight ratio | 2.63±0.18 | 2.74±0.11 | 0.65 | 0.74 | 0.93 |
| Fetal liver weight, g | 29.92±6.54 | 25.16±2.00 | 0.51 | 0.74 | 0.74 |
| Fetal liver-to-brain weight ratio | 0.04±0.01 | 0.04±<0.01 | 0.83 | 0.83 | 0.74 |
| Female | 3/6 (50%) | 5/5 (100%) | 0.18 | 0.60 | 0.74 |
Values are means ± SE; n, no. of animals. FDR, false discovery rate. P < 0.05 is considered significant. Unadjusted P values are from t-tests, and the last column gives the FDR correction for multiple t-tests.
†
Wilcoxon Rank Sum used instead of t-test (see materials and methods).
*
P value is following FDR correction, with removal of the unoperated control fetus that did not receive saline infusions compared with nicotine-exposed fetuses.