Table 5.

Frequencies of NFKBIA promoter haplotypes in subgroups of patients with Graves' disease stratified by clinical activity of thyroid associated ophtalmopathy assessed according to the NOSPECS classification.

Gene	polymorphism 1	polymorphism 2	Ophtalmopathy
			NOSPECS ≥ III	NOSPECS ≤ II
NFKBIA	-297 C/T	-826 C/T	N = 170 (%)	N = 289 (%)
haplotypes	C	C	126 (74.0)	238 (82.3)
	T	T	31 (18.4)	33 (11.3)
	T	C	8 (4.8)	11 (3.9)
	C	T	5 (2.8)	7 (2.5)

Haploview software was used to construct haplotypes from population genotype data and to assess possible difference in their distribution. The distribution of NFKBIA promoter haplotypes differed significantly between subgroups of GD subjects stratified by the presence of clinically evident ophthalmopathy (p = 0.003).