Table 1.
Auxiological data for the study groups
| A) Total group (n = 128; 38 girls, 90 boys) | B) ISS (n = 89, 25 girls, 64 boys) | C) GHD (n = 39, 13 girls, 26 boys) | |||||||
| Variables | Median | Min | Max | Median | Min | Max | Median | Min | Max |
| At birth | |||||||||
| Gestational age (weeks) | 39 | 33 | 42 | 39 | 33 | 42 | 39 | 36 | 42 |
| Height SDS | -0,66 | -2,52 | 1,68 | -0,74 | -2,52 | 1,68 | -0,70 | -2,52 | 1,68 |
| At GH start | |||||||||
| Age (yrs) | 7,27 | 3,05 | 10,95 | 7,32 | 3,24 | 10,95 | 7,14 | 3,05 | 10,94 |
| Height SDS | -2,64 | -4,10 | -1,77 | -2,64 | -4,10 | -1,77 | -2,59 | -3,65 | -1,98 |
| Weight SDS | -2,24 | -4,31 | 0,26 | -2,39 | -4,31 | -0,45 | -2,03 | -3,80 | 0,26 |
| BMI SDS | -0,47 | -3,35 | 2,11 | -0,55 | -3,35 | 1,88 | -0,20 | -1,80 | 2,11 |
| GHmax AITT (mU/L) | 16,95 | 1,10 | 62,90 | 19,60 | 1,10 | 62,90 | 15,10 | 1,60 | 22,30 |
| GHmax 24 h (mU/L) | 24,85 | 0,80 | 58,10 | 28,10 | 12,70 | 58,10 | 14,70 | 0,80 | 22,10 |
| Diff MPHSDS | -1,73 | -3,53 | -0,61 | -1,72 | -3,53 | -0,61 | -1,77 | -2,45 | -0,78 |
| HDL (mg/L) | 1,44 | 0,64 | 2,70 | 1,44 | 0,64 | 2,70 | 1,44 | 0,91 | 2,24 |
| IGF-I SDS | -1,10 | -5,17 | 2,25 | -1,19 | -3,84 | 2,25 | -1,06 | -5,17 | 0,91 |
| GH dose (μg/kg/day) | 44,20 | 17,00 | 102,00 | 44,20 | 17,00 | 102,00 | 44,20 | 17,00 | 68,00 |
| After 2 yrs of treatment | |||||||||
| Height SDS | -1,45 | -3,00 | 0,20 | -1,45 | -3,00 | 0,20 | -1,45 | -2,42 | 0,05 |
| Delta height SDS 2 yrs | 1,26 | 0,23 | 2,69 | 1,22 | 0,23 | 2,69 | 1,31 | 0,51 | 2,39 |
| BMI SDS | -0,24 | -3,10 | 2,03 | -0,05 | -3,10 | 1,88 | -0,08 | -2,14 | 2,03 |
| HDL (mg/L) | 1,36 | 0,76 | 2,06 | 1,37 | 0,76 | 2,06 | 1,28 | 0,94 | 1,97 |
| IGF-I SDS | 1,57 | -1,48 | 4,21 | 1,49 | -0,65 | 3,82 | 1,57 | -1,48 | 4,21 |
AITT, arginine--insulin tolerance test; GHmax, maximum peak of GH secretion; IGF-I, insulin-like growth factor I; GHD, GH deficient; MPH, mid-parental height; diffMPHSDS, difference in height SDS of the child versus its mid-parental height SDS
0.1 U GH/kg/day = 33 μg/kg/day
The reference values used for SDS calculations were obtained from [18] for height and weight and [15] for IGF-I.