Table 1.
Candidate Genes for Alcohol Consumption by HXB/BXH RI Rats.
| Gene Symbol | Gene Description | Gene Location Chr(Mb) | eQTL Location Chr(Mb) | eQTL Mb Range | eQTL LOD (p-value) | bQTL Location Chr(Mb) | Correlation Coefficient (p-value) | Broad Sense Heritability | Percent Present |
| Cckbr | cholecystokinin B receptor | 1 (163.17) | 1 (168.95) | 139.73-179.97 | 6.3 (<0.001) | 1 (159-194) | 0.61 (0.0023) | 0.82 | 100% |
| Coq7 | demethyl-Q 7 (Coenzyme q (ubiquinone) biosynthetic enzyme (DHPB methyltransferase) 7) | 1 (176.76) | 1 (177.64) | 152.25-179.75 | 9.0 (<0.001) | 0.55 (0.0059) | 0.93 | 100% | |
| Fgfr2 | fibroblast growth factor receptor 2 isoform c | 1 (189.48) | 1 (184.63) | 173.38-184.63 | 20.7 (<0.001) | 0.58 (0.0029) | 0.99 | 93% | |
| Ptpre | protein tyrosine phosphatase receptor type E | 1 (195.16) | 1 (195.13) | 184.63-196.57 | 13.1 (<0.001) | -0.43 (0.0348) | 0.95 | 100% | |
| Abat | 4-aminobutyrate aminotransferase | 10 (7.04) | 1 (132.04) | 12.84-249.11 | 4.2 (0.027) | -0.51 (0.0267) | 0.56 | 100% | |
| Tpst1 | tyrosylprotein sulfotransferase 1 (predicted) | 12 (27.59) | 1 (15.55) | 9.02-205.67 | 3.1 (0.096) | 0.51 (0.0265) | 0.54 | 99% | |
| Tmem2 | transmembrane protein 2 | 1 (225.04) | 1 (223.19) | 39.64-254.91 | 3.7 (0.065) | 1 (213-238) | 0.53 (0.0095) | 0.85 | 100% |
| Mboat2 | membrane bound O-acyltransferase domain | 6 (42.49) | 6 (38.84) | 18.53-131.90 | 3.5 (0.072) | 6 (33-53) | 0.43 (0.0455) | 0.73 | 100% |
| Dynlrb1 | dynein light chain roadblock-type 1 | 3 (145.72) | 6 (38.84) | 18.53-115.00 | 3.6 (0.095) | 0.44 (0.0456) | 0.66 | 100% | |
| Tnk2 | tyrosine kinase, no-receptor, 2 | 11 (69.93) | 6 (25.68) | 0.27-38.84 | 4.0 (0.010) | -0.50 (0.0212) | 0.68 | 100% | |
| Nek3 | NIMA (never in mitosis gene a)-related expressed | 16 (74.52) | 6 (37.98) | 25.56-37.98 | 4.1 (0.008) | -0.43 (0.0499) | 0.69 | 97% | |
| Afap1l1 | actin filament associated protein 1-like 1 | 18 (57.71) | 6 (33.80) | 25.68-50.93 | 3.3 (0.090) | 0.49 (0.0227) | 0.74 | 100% | |
| Mc4r | melanocortin 4 receptor | 18 (63.39) | 6 (33.80) | 33.80-50.93 | 3.7 (0.006) | 0.46 (0.0417) | 0.59 | 96% | |
| Tubb6 | tubulin beta 6 | 18 (63.92) | 6 (33.80) | 33.80-124.56 | 3.2 (0.097) | 0.47 (0.0344) | 0.63 | 98% | |
| Spire1 | spire homolog 1 | 18 (64.02) | 6 (33.80) | 18.53-98.70 | 3.4 (0.025) | 0.53 (0.0109) | 0.77 | 100% | |
| Mogat2 | monoacyglycerol O-acyltransferase 2 | 1 (156.52) | 12 (34.31) | 29.92-38.52 | 3.5 (0.028) | 12 (25-46) | -0.45 (0.0353) | 0.78 | 98% |
| F2rl1 | proteinase-activated receptor-2 G protein coupled | 2 (25.89) | 12 (38.52) | 36.18-43.30 | 2.8 (0.059) | 0.53 (0.0224) | 0.52 | 52% | |
| P2rx4 | P2X purinoceptor 4 (ATP receptor) | 12 (34.94) | 12 (34.50) | 13.40-34.50 | 5.1 (0.003) | -0.70 (0.0004) | 0.80 | 100% | |
| Rab35 | RAB35 member RAS oncogene family | 12 (42.23) | 12 (41.98) | 38.21-43.30 | 9.0 (<0.001) | 0.45 (0.0296) | 0.91 | 100% | |
| Pop5 | processing of precursor 5 ribonuclease P/MRP | 12 (42.64) | 12 (41.98) | 36.18-43.30 | 4.4 (0.025) | -0.54 (0.0125) | 0.68 | 100% | |
All transcripts listed displayed an eQTL/bQTL overlap, showed a significant correlation with alcohol consumption, and passed the filters for heritability and detectability of expression.