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View full-text article in PMC

. Author manuscript; available in PMC: 2009 Nov 16.

Published in final edited form as: Mol Imaging. 2008 MAY-JUN;7(3):118–131.

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A). Scheme for the synthesis of PB-M7NIR, a (Cy5-M7)8-PAMAM-(PEG5000) (AF750)6 co-polymer. SIA = N-Succinimidyl iodoacetate B.)The Cy5.5 optical sensor is linked via AHX to the N-terminus of the MMP selective cleavable peptide (RPLA*LWRS, cleavage site denoted by asterisk) that is coupled via a second AHX and Cysteine with the PAMAM. The internal reference, AF750, of PB-M7NIR is linked directly to the dendrimer (Starburst® PAMAM dendrimer, Generation 4). Structure is not drawn to scale.

A). Scheme for the synthesis of PB-M7NIR, a (Cy5-M7)8-PAMAM-(PEG5000) (AF750)6 co-polymer. SIA = N-Succinimidyl iodoacetate B.)The Cy5.5 optical sensor is linked via AHX to the N-terminus of the MMP selective cleavable peptide (RPLA*LWRS, cleavage site denoted by asterisk) that is coupled via a second AHX and Cysteine with the PAMAM. The internal reference, AF750, of PB-M7NIR is linked directly to the dendrimer (Starburst® PAMAM dendrimer, Generation 4). Structure is not drawn to scale.